WebThe glutathione S-transferase protein family is important in detoxification within the cell and can protect the lens from oxidative stress [102]. Polymorphisms within the glutathione S-transferase Mu 1 (GSTM1) gene have been associated with increased risk for age-related cataracts, especially with exposure of smoking [103, 104]. The activity of GSTs is dependent upon a steady supply of GSH from the synthetic enzymes gamma-glutamylcysteine synthetase and glutathione synthetase, as well as the action of specific transporters to remove conjugates of GSH from the cell. The primary role of GSTs is to detoxify xenobiotics by catalyzing the nucleophilic attack by GSH on electrophilic carbon, sulfur, or nitrogen atoms of said nonpolar xenobiotic substrates, thereby preventing their interaction with crucial ce…
Anti Cancer Effects and Tumor Marker Role of Glutathione …
WebGlutathione S-transferase Mu 4 is an enzyme that in humans is encoded by the GSTM4 gene. Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega ... WebApr 1, 1999 · Incubation of S-(4-bromo-2,3-dioxobutyl)glutathione (S-BDB-G), a reactive analogue of glutathione, with the 1-1 isoenzyme of rat liver glutathione S-transferase at pH 6.5 and 25 degrees C results ... auton pohjan öljyäminen
Human glutathione S-transferases - PubMed
WebGlutathione S-transferase (GST) is a kind of multifunctional supergene family enzymes, widely distributed in mammals, birds, insects, ... The LOD and LOQ of GST was lower to be 0.19 mU·L −1 and 0.57 mU·L −1. The relative standard deviations at different concentrations in three replicates for GST detection are lower than 3.85% ... WebGlutathione S-transferase Mu 4 Molecular Weight 25561.095 Da. References. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. … auton pitkäaikaisvuokraus