Human p16ink4a protein
p16 (also known as p16 , cyclin-dependent kinase inhibitor 2A, CDKN2A, multiple tumor suppressor 1 and numerous other synonyms), is a protein that slows cell division by slowing the progression of the cell cycle from the G1 phase to the S phase, thereby acting as a tumor suppressor. It is … Meer weergeven p16 is also known as: • p16 • p16 • Cyclin-dependent kinase inhibitor 2A (CDKN2A) • CDKN2 Meer weergeven p16 is an inhibitor of cyclin-dependent kinases (CDK). It slows down the cell cycle by prohibiting progression from G1 phase to S phase. Otherwise, CDK4/6 binds cyclin … Meer weergeven Role in carcinogenesis Mutations resulting in deletion or reduction of function of the CDKN2A gene are associated with increased risk of a wide range of cancers, and alterations of the gene are frequently seen in cancer cell lines. … Meer weergeven Researchers Manuel Serrano, Gregory J. Hannon and David Beach discovered p16 in 1993 and correctly characterized the protein as a … Meer weergeven In humans, p16 is encoded by the CDKN2A gene, located on chromosome 9 (9p21.3). This gene generates several transcript variants … Meer weergeven Regulation of p16 is complex and involves the interaction of several transcription factors, as well as several proteins involved in epigenetic modification through methylation … Meer weergeven Biomarker for cancer types Expression of p16 is used as a prognostic biomarker for certain types of cancer. The reason for this is different types of cancer can have different effects on p16 expression: cancers that overexpress p16 are usually … Meer weergeven Web21 jan. 1997 · The INK4a gene, one of the most frequently disrupted tumor suppressor loci in human cancer, encodes two unrelated proteins, p16 INK4a and p19 ARF, each of …
Human p16ink4a protein
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WebInvitrogen Anti-p16INK4a Recombinant Monoclonal (10H23L14), Catalog # 703831. Tested in Western Blot (WB) and Immunocytochemistry (ICC/IF) applications. This antibody … WebSanta Cruz Biotechnology) against human full length p16, rabbit polyclonal H-156 (sc-759, Santa Cruz Biotechnology) against human full length p16INK4a and mouse monoclonal …
Webp16INK4A Rabbit Monoclonal Antibody -20℃保存，Western一抗稀释液-20℃或4℃保存，一年有效。 Western一抗稀释液优先推荐4℃保存，长期不使用可以考虑-20℃保存，但冻融可能会导致出现轻微的浑浊和少量不溶物。 注意事项: 如果本抗体用于Western blot (WB)、免疫荧光 (IF)、免疫细胞化学 (ICC)等实验，请注意回收使用过的稀释抗体。 回收的抗体通 … WebNo extensive p16INK4A genomic alterations were found in tumors lacking p16-protein expression. To deter-mine which mechanisms are involved in the down-regulation of p16 protein, the methylation status of the p16INK4 gene was evaluated on the 15 p16-negative tumors: 8 samples showed 58 CpG-island methylation; 4/8 had a complete meth-
WebMouse Monoclonal CDKN2A / p16INK4a antibody [MX007]. Validated in WB, IHC-P. Tested in Human. Cited in 3 reference(s). United States (US) Country ... Recombinant human p16INK4a protein (aa1-156) Purification Purified IgG Conjugation Unconjugated. Note For laboratory use only. Not ... Web28 okt. 2024 · The composition of the CDKN2Alocus is quite unique for the human genome, as it codes for two unrelated proteins: p14ARF and p16INK4a (hereafter referred to as p14 and p16). The two genes share exon 2 and 3 but have distinct first exons, start sites and promoters, resulting in different open reading frames.
Web24 mrt. 2024 · The INK4A gene encodes a 16 kDa small molecule protein called P16 INK4A, also known as cell cycle-dependent protein kinase inhibitor 2A (CDKN2A) [ 13, …
Web1 mrt. 1998 · Homozygous deletion of the p16/INK4a gene and the p15/INK4b gene that maps in tandem with p16/INK4a on chromosome 9p21 was first observed in many … buy tapeworms for weight lossWeb21 feb. 2024 · Product Name : Human p16INK4a Synthetic Peptide Catalog # : PEP-0496 Quantity : 50 µg Price : US 140.00 Clonality : Synthetic Purity : purified Reactivity : … certificate for website freeWeb21 jun. 2024 · CDKN2A now being the official gene symbol. The human p16INK4A gene is located on the short arm of chromosome 9 (9p21.3) while the mouse gene is located on … certificate for typing speed