Ion-827359
WebA study medication called ION-827359 is being developed to treat lung disease symptoms in people with cystic fibrosis. The study medication is intended to help treat the thick mucus … WebBackground: Eluforsen is an antisense oligonucleotide designed to bind to the mRNA region around the F508-encoding deletion and restore the cystic fibrosis transmembrane …
Ion-827359
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WebHome - n-Lorem FOUNDATION WebA Study to Assess the Safety, Tolerability, and Efficacy of ION-827359 in Patients With Mild to Moderate Chronic Obstructive Pulmonary Disease (COPD) With Chronic Bronchitis …
WebInterpretation This study provides good evidence for the tolerability and safety of ION-827359. The reduction in ENaC mRNA supports mechanistic efficacy at the doses and … WebFull Analysis Set (FAS) included all randomised subjects who received at least 1 dose of study drug (ION‑827359 or placebo) and who had at least 1 post-Baseline efficacy …
Web20 apr. 2024 · ION-827359 is a 2·5-generation antisense oligonucleotide drug targeted to reduce the ENaC protein. This study evaluated the safety, pharmacokinetics (PK), and … WebION-827359 is a chemically modified ASO, 16 nucleotides in length with a phosphorothioate backbone and constrained ethyl (cEt) modifications. In healthy volunteers the ASO was …
Web12 aug. 2024 · The BALANCE-CFTM 1 phase II trial in patients with CF was safe, but did not demonstrate a potential for clinical benefit, and development has been terminated. …
Web1 jan. 2024 · Inhalation of small molecule drugs has proven very efficacious for the treatment of respiratory diseases due to enhanced efficacy and a favourable the… software packages for schoolWebSchneider Electric Global. Browse our products and documents for PowerLogic ION7300 series - Highly-configurable meters for feeders or critical loads software packages for customer supportWebThis is a multi-center, double-blind, placebo-controlled, randomized, Phase 2a study of ION-827359 in up to 180 participants. The participants will be randomized to receive oral … software packages used in businessWeb23 dec. 2024 · ION-827359 from Ionis is an inhalable Gapmer ASO formulation being developed for CF to assess the hyperactivity of ENaCs, though this trial has been paused due to safety concerns. The ASO sequence has the (S)-cEt modification that provides excellent target affinity and nuclease resistance. slow kitchen drain bubblesWebA Double-Blind, Placebo-Controlled, Dose-Escalation, Phase 1/2a Study to Assess the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single and Multiple … software package management in linuxWebION-827359 SODIUM Code; ION-827359, SODIATED FORM Code; UNII Resources. Common Chemistry CAS Common Chemistry is an open community resource of the American Chemical Society for accessing chemical information. software paea datashowWeb11 mei 2024 · ion-827359. Showing 1 - 1 of 1. Trials per page: STUDY. CONDITIONS. INTERVENTIONS. LOCATIONS. LAST UPDATED Chronic Bronchitis, COPD Trial in … slow kitchen drain