Irf2bp2 cancer
WebInterferon regulatory factor 2 binding protein 2 (IRF2BP2) was originally identified as a transcriptional corepressor. However, the association between IRF2BP2 and the Hippo … WebJul 31, 2024 · Overall, cases 12 (harboring IRF2BP2-NTRK1 ), 13 ( PPL- NTRK1 ), and 25 ( ETV6-NTRK3) were morphologically similar, composed of lobules of partially fused papillae with scattered glomeruloid...
Irf2bp2 cancer
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WebMay 19, 2016 · The IRF2BP2–CDX-1 fusion gene has been reported in mesenchymal chondrosarcoma, 16 and there is one previous report of IRF2BP2–RARA in APL. 10 Yin et al. 10 reported a case of APL with IRF2BP2–RARA that involved exon 2 of IRF2BP2 and intron 2 of RARA, with breakpoints at positions 1687 bp in IRF2BP2 and 41620 bp in RARA. The … WebJul 29, 2024 · Translocations and mutations in the human irf2bp2gene have been observed in various cancers including primary central nervous system lymphoma (Pall & Hamilton, 2008), multiple myeloma (Ni et al.,2012), mesenchymal chondrosarcoma (Nyquist et al.,2012) and acute promyelocytic leukemia (Yin et al.,2015), emphasizing the importance …
WebIRF2BP2-NTRK1 Fusion is present in 0.02% of AACR GENIE cases, with sarcoma, NOS, breast invasive ductal carcinoma, gastric adenocarcinoma, lung adenocarcinoma, and pancreatic acinar cell carcinoma having the greatest prevalence [ 4 ]. Top Disease Cases with IRF2BP2-NTRK1 Fusion References 1. WebIRF2BP2_ENST00000366610 Sequences You can see various sequences for this gene: cDNA (ENST00000366609.3) Protein (IRF2BP2) Transcript and protein aligned …
WebJul 20, 2015 · IRF2BP2 is a cofactor modulating IRF2 and myocyte enhancer factor 2 (MEF2), transcription factors important for innate immunity and gene expression in macrophages. 8 – 12 Exposure of macrophages to bacterial lipopolysaccharide activates the M1 inflammatory phenotype, whereas exposure to interleukin (IL)-4 favors the M2 anti … WebMar 21, 2024 · IRF2BP2 (Interferon Regulatory Factor 2 Binding Protein 2) is a Protein Coding gene. Diseases associated with IRF2BP2 include Immunodeficiency, Common …
WebApr 25, 2024 · Additionally, IRF2BP2 may be involved in cancer development. Finally, it has been recently reported that IRF2BP2 may play a role in macrophage regulation and lymphocyte activation, highlighting ...
WebSep 20, 2024 · IRF2BP2 stabilized VGLL4 protein and repressed tumor progression via the inactivation of YAP-TEAD4 complex in liver cancer (41). In contrast, IRF2BP2 repressed … east park avenue apartments tallahasseehttp://english.cemcs.cas.cn/news/202411/t20241120_252214.html culver\u0027s shrimp basket priceWebApr 25, 2024 · The IRF2BP2 (IFN regulatory factor 2 binding protein 2) protein was identified as a nuclear protein that interacts with IFN regulatory factor 2 (IRF-2) and is an IRF-2 … culver\u0027s shakes flavorsWebInterferon regulatory factor 2 binding protein 2 is a protein that in humans is encoded by the IRF2BP2 gene. Function. This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding ... east park chippy menuWebApr 8, 2024 · The researchers discovered Richter syndrome-specific somatic driver mutations in genes including IRF2BP2, SRSF1, B2M, DNMT3A, and CCND3. They also found recurrent copy-number alterations beyond del(9p21)(CDKN2A/B), whole-genome duplication and chromothripsis, which they confirmed in 45 independent Richter syndrome cases and … culver\u0027s sheboygan washington aveWebSep 25, 2015 · In a recent issue of Circulation Research, Chen et al report that IRF 2–binding protein 2 (IRF2BP2) is a novel regulator of macrophage inflammation and lipid homeostasis that acts by maintaining anti-inflammatory transcription factor Krüppel-like factor 2 (KLF2) expression, therefore reducing susceptibility to atherosclerosis 6 ( Figure 2 ). culver\u0027s shrimp basket menu with pricesWebIRF2BP2 is involved in 1 fusion, with the following gene: CDX1 (1 mutation in 4 samples) Drug sensitivity data Mutations in IRF2BP2 are associated with altered sensitivity to the following 10 drugs: Dactolisib Docetaxel SN-38 Show all See all drug sensitivity data for IRF2BP2. External links culver\u0027s sioux city ia