WebPhospho‑STAT1 expression as a potential biomarker for anti‑PD‑1/anti‑PD‑L1 immunotherapy for breast cancer Phospho‑STAT1 expression as a potential biomarker for anti‑PD‑1/anti‑PD‑L1 immunotherapy for breast cancer Authors WebThe expression of phosphorylated signal transducer and activator of transcription 1 (p‑STAT1), one of the IFN‑γ signaling pathway molecules, was analyzed using …
Did you know?
WebMar 31, 2024 · STAT1 is localized predominantly in the cytoplasm prior to cytokine stimulation and upon receptor activation by IFNγ, the receptor-associated JAKs phosphorylate a critical tyrosine residue at position 701 in the STAT1 transactivation domain producing phosphorylated STAT1 (P-STAT1). WebSTAT1 Phospho (Tyr701) A17012A : ICFC, ICC, WB, ChIP: STAT1 Phospho (Ser727) A15158B : ICFC, ICC, WB, ChIP: STAT3 Phospho (Ser727) A16089B : ICFC, WB, ChIP: Need a control for your phospho flow cytometry staining? Our Veri-Cells™ Phospho PBMCs can be used as a positive and negative control for staining members of the MAPK/ERK pathway.
WebJan 28, 2024 · STAT1,货号：Thermo Pierce MA119323,规格：100 µg Phospho-STAT1 pSer727,货号：Thermo Pierce MA119325,规格：100 µg NTAL,货号：Thermo Pierce MA119327,规格：100 µg NTAL,货号：Thermo Pierce MA119329,规格：100 µg Fyn,货号：Thermo Pierce MA119331,规格：100 µg WebAnti-phospho-STAT1 (Tyr701) Antibody is a Rabbit Polyclonal Antibody for detection of phospho-STAT1 (Tyr701) also known as Transcription factor ISGF-3 components p91/p84 & has been validated in WB. Research Category Epigenetics & Nuclear Function. Research Sub Category Transcription Factors.
WebA nuclear phospho-tyrosyl phosphatase TC-PTP has been shown to dephosphorylate STAT1. STAT1 is exported back to the cytoplasm and this terminates STAT1-stimulated … WebA phospho specific peptide corresponding to residues surrounding Serine 727 of human Stat-1 was used as an immunogen. This antibody only detects Stat-1 phosphorylated at Serine 727. Tested applications Suitable for: WB, …
WebInvitrogen Anti-Phospho-STAT1 (Tyr701) Monoclonal (ST1P-11A5), Catalog # 33-3400. Tested in Western Blot (WB), Immunohistochemistry (Paraffin) (IHC (P)), ChIP assay …
WebMar 31, 2024 · Our data demonstrate a novel role of U-STAT1 in affecting nuclear accumulation of P-STAT1, such that a high intracellular concentration of U-STAT1 inhibits … song holding back the tearsWebMar 21, 2024 · STAT1 (Signal Transducer And Activator Of Transcription 1) is a Protein Coding gene. Diseases associated with STAT1 include Immunodeficiency 31C and Immunodeficiency 31B . Among its related pathways are IL-9 Signaling Pathways and Prolactin Signaling . Gene Ontology (GO) annotations related to this gene include DNA … song holding on to yesterdayWebStat1 has two alternatively spliced isoforms, 91-kDa Stat1α and 84-kDa Stat1β; Stat1α has 38 additional C-terminal amino acids. In response to the binding of IFNα, IFNγ, EGF, PDGF, … song holding things togetherWebSTAT1, also known as signal transduction and activator of transcription 1, is a ubiquitously expressed cytoplasmic protein and is activated in response to cytokine signaling, including IFN-α, IFN-γ, EGF, PDGF, and IL-6. Upon activation, STAT1 is phosphorylated at Tyrosine 701 (Tyr701) by receptor-associated kinases, including JAK1, JAK2, and ... song hold me up so i can flyWebOct 30, 2024 · STAT1 expression can rescue the erythroid phenotype caused by arhgef12 knockdown in zebrafish. Human STAT1 produces two splicing variants that differ at their carboxy terminus. ... Phospho-flow histograms of phospho-p38 on pro-erythroblasts with different rs10892563 genotypes. Phosphorylated p38 was stained with anti-pT180/pY182 … song holding her and loving youWebPhospho-STAT1 regulates pro- and anti-apoptotic genes following several stress-induced responses. It interacts with p53 and promotes p53-mediated transcriptional gene activity and apoptosis. STAT1 is also an essential factor of stress-induced and DNA damage-induced checkpoint pathways and thus, acts as a tumor suppressor. 1 4 2. song hold my haloWebNov 29, 2024 · IFN-I is the key regulatory component activating and modulating the response of innate and adaptive immune system to bacterial as well as viral pathogens. IFN-I promotes the expression of IFN-induced genes (ISG) and, consequently, the production of chemokines, e.g., CXCL10. Those chemokines control migration and localization of … small esky cooler