Phosphorylation of irf3 antibody
WebNational Center for Biotechnology Information Web研究背景. P18206_VINC_HUMAN. 功能: Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion.
Phosphorylation of irf3 antibody
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WebSep 1, 2024 · Although phosphorylation of Ser82 phenocopies that of Ser339 and Ser97 in IFN-β activation, it controls the promoter binding ability of IRF3, an activation step … WebPhospho-IRF-3 (Ser396) Antibody detects endogenous levels of IRF-3 only when phosphorylated at Ser396. This antibody does not cross-react with other family members at physiological conditions. Species Reactivity: Human. Species predicted to react based on … Highly specific and rigorously validated in-house, Phospho-IRF-3 (Ser396) (4D4G) …
WebMar 8, 2024 · The dimerization and phosphorylation of IRF3 as well as the phosphorylation of TBK1 are hallmarks of the cytosolic DNA-triggered signaling. These processes were apparently inhibited in Rnf185 knockdown L929 cells, when stimulating cells with HT-DNA (Figs 2A and S4A ). WebKey features and details Rabbit polyclonal to IRF3 (phospho S396) Suitable for: WB Reacts with: Human Isotype: IgG You may also be interested in Primary Anti-IRF3 (phospho S386) antibody [EPR2346] - BSA and Azide free (ab182859) Protein Recombinant Human IRF3 protein (ab205216) Secondary Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
WebJan 20, 2009 · In this study, we show that another kinase, c-Jun-NH2-terminal kinase (JNK), phosphorylates IRF3 on its N-terminal serine 173 residue, and TAK1 can stimulate IRF3 … WebD, IRF3 phosphorylation is inhibited by E3L. 293T cells were transfected with 10 μg of an IRF3 expression vector and 10 μg of E3L (lanes 3 and4) or K3L (lanes 5 and 6), infected …
WebControl of IRF-3 activation by phosphorylation Interferon (IFN) regulatory factor-3 (IRF-3) is a unique member of the IRF family. Its transcriptional activity is regulated solely by …
WebPhospho-IRF3 (Ser396) Antibody (720012) in ICC/IF. Immunofluorescence was performed on fixed and permeabilized HeLa cells treated with Calyculin A (50 ng/mL/20 min) for … crystal uplightWebApr 11, 2024 · In the TLR4-TRIF-IRF3-type I IFN signaling cascade, phosphorylation of the TBK1 kinase is a key step 2. Phosphorylated-TBK1 (pTBK1) subsequently phosphorylates IRF3, which then translocates... crystal upvc french doorsWebMar 1, 2024 · The innate sensor ZBP1-IRF3 axis regulates cell proliferation in multiple myeloma - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. crystal updateWebWith chromatin immunoprecipitation assays, we have now investigated whether histone methylation and phosphorylation are also involved in transcriptional regulation by thyroid hormone receptor (TR). We found that repression by unliganded TR is associated with a substantial increase in methylation of H3 lysine 9 (H3-K9) and a decrease in ... crystal upholstery buttons for tuftingWebTBK1-dependent phosphorylation of IRF3 leads to its nuclear translocation and subsequent activation of transcriptional programs that ultimately lead to the production of inflammatory cytokines, ... Staining with a dsDNA-specific antibody showed that such treatment is sufficient to induce cytosolic accumulation of dsDNA (Fig 1J, ... dynamic metal traders incWebIt is now well established that TBK1 is responsible for IRF3 phosphorylation in response to stimulation of several intracellular receptors that induce type-I interferons, including TLR3, … dynamic metals group llcWebDeficiency of STING prevented IRF3 phosphorylation by ethanol or ER stress, and absence of IRF3 prevented hepatocyte apoptosis. The pathogenic role of IRF3 in ALD was independent of inflammation or Type-I interferons. Thus, STING and IRF3 are key determinants of ALD, linking ER stress signaling with the mitochondrial pathway of … crystal upholstery buttons