WebThe invention provides an amantadine hapten A or B. The preparation method of the invention gradually prepares the amantadine antigen A or B. Then obtaining the anti-amantadine monoclonal antibody 3G7, the amantadine ELISA detection kit and the amantadine biochip detection kit prepared by the components can detect amantadine in … WebDec 8, 2011 · The M2 channel protein on the influenza A virus membrane has become the main target of the anti-flu drugs amantadine and rimantadine. The structure of the M2 channel proteins of the H3N2 (PDB code 2RLF) and 2009-H1N1 (Genbank accession number GQ385383) viruses may help researchers to solve the drug-resistant problem of these two …
An Improved Synthesis of Amantadine Hydrochloride - ScienceDirect
WebNov 29, 2014 · Synthesis of amantadine-based ion pair amphiphiles. As AT is slightly soluble in water and is soluble in ethyl alcohol, while OA is a monounsaturated ω-9 fatty acid which is soluble in ethyl alcohol and insoluble in water. Thus we chose anhydrous ethyl alcohol as the solvent of AT and OA. WebDec 1, 2024 · One of the original methods of making amantadine hydrochloride (amantadine HCl) included [1] the hydrolysis of 1-acetamidoadamantane to form amantadine, [2] its separation by steam distillation, and [3] the formation of amantadine HCl salt. Firstly, the reaction time for the synthesis of amantadine at 100ºC was shortened. münchen ticket tollwood
Recent Advances in Process Development of Antiviral Agents …
WebAmantadine hydrochloride is an antiviral drug used in prevention and treatment of influenza A infections. It has also been used for alleviating early symptoms of Parkinson’s disease. Several methods for the preparation of Amantadine hydrochloride have been reported overall yields ranging from 50% to 52%. WebJan 30, 2024 · A monoclonal antibody (mAb) was produced in order to monitor the illegal use of amantadine and rimantadine in animals. The produced mAb 2G3 exhibited an IC 50 value of 15.8 μg L −1 for amantadine and exhibited cross-reactivity to both amantadine (100%) and rimantadine (70.6%). Standard curves ranged from 5 to 80 μg L −1 for 2G3. … münchen stadion tour