Taut gene

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WebDec 17, 2015 · The TauT deletion constructs of pGL3/TauT (−124 to +46 bp and −99 to +46 bp) and the TauT mutation construct of pGL3/TauT/-124-Luc were generated by PCR. The plasmid was transfected into HCMs ... WebOct 18, 2002 · To determine whether down-regulation of the TauT gene by p53 occurs at the transcriptional level, the reporter construct pGL-963, containing a putative p53 …

Taurine transporter (TauT) deficiency impairs …

Webtauto-: prefix meaning "same": tautomenial, tautomeral, tautomerism. WebDec 28, 2001 · Taut gene disruption by homologous recombination. A) Scheme of the wild-type taut locus, the targeting (replacement) vector, and the predicted structure of the … nickname before wayne or kim

Disruption of the taurine transporter gene (taut) leads to retinal ...

WebAug 24, 2010 · Studies have shown that TauT is regulated by variety of stresses, including tonicity, oxidation, DNA damage, and dietary manipulation [ 17 – 20 ], suggesting that TauT is a stress response gene. However, there are little data available about signaling pathway (s) that may be involved in stress-induced TauT regulation. WebDec 28, 2001 · The taut knockout mice were generated by homologous recombination and had a mixed genetic background (C57Bl/6 × 129/SvJ). Animals were housed in isolators at a 12–12 h light-dark cycle, according to the rules of the local ethical guidelines. Screening of the recombinant embryonic stem cells WebThe previously revealed downregulation of TauT expression by taurine and hypertonicity-induced upregulation of TauT expression were shown to result from a modified transcription rate of TauT gene, but the precise molecular mechanisms are not yet formally established. novritsch ssg 10 a3 lenght

Significance of taurine transporter (TauT) in homeostasis and its ...

29464 - Gene ResultSlc6a6 solute carrier family 6 member 6

WebIn order to clone the upstream region of the human TAUT promoter, we have compared TAUT cDNA sequences with the entire human genome sequence. Polymerase chain reaction (PCR) was performed from genomic DNA prepared from a SK-Hep-1 cell line for the amplification of the TAUT promoter region including the partial exon (150 bp) and the 5 ... WebThe disruption of TauT function by either pharmacologic agents or its genetic invalidation (TauT KO mice) induces severe taurine depletion in the plasma leading to undetectable taurine concentrations in some tissues. This effect is probably a consequence of taurine uptake inhibition at the intestinal level. nickname britsh wwhelmetWebJul 9, 2024 · The TauT transporter ( SLC6A6 gene) is considered the major transporter, which is characterized by its dependence on ions (sodium or chloride), the high affinity and the low capacity against its substrates. nickname bud short for

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Taut gene

Taurine transporter (TauT) deficiency impairs …

WebTaut definition, tightly drawn; tense; not slack. See more. WebTau is the major component of the intracellular filamentous deposits that define a number of neurodegenerative diseases, including the largely sporadic Alzheimer's disease, …

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WebThe taurine transporter (TAUT, SLC6A6) cotransports taurine, along with two sodium ions and one chloride ion, into endothelial cells of the proximal renal tubule (Chesney et al., … WebRenal adaptive regulation of the taurine transporter (TauT) was studied in vivo and in vitro. Site-directed mutagenesis and the oocyte expression system were used to study post …

WebGlucose causes dysfunction of taurine uptake and downregulation of TAUT gene expression in cultured rat cardiomyocytes. TauT (along with system A) plays a cytoprotective role in …

WebTauT gene expression is significantly upregulated in mononuclear leukocytes of type 1 diabetes patients and is related to HbA1c levels and inversely to plasma homocysteine. CNDP1 and CARNS are expressed in glomeruli and tubular cells; TauT is expressed in … WebTaurine is thought to be an osmolyte in the kidney medulla. We have investigated the gene expression of the taurine transporter (TauT) and the enzymes of taurine biosynthesis, cysteine dioxygenase (CDO) and cysteine sulfinate decarboxylase (CSD).

WebMar 21, 2024 · This gene encodes a multi-pass membrane protein that is a member of a family of sodium and chloride-ion dependent transporters. The encoded protein …

WebApr 25, 2024 · Taurine transport is mainly achieved by taurine transporters (TauT). In normal tissues, the intracellular concentration of taurine is much higher than the extracellular concentration. The active transport of taurine through the TauT requires 23 sodium ions and one chloride ion for transport into the cytoplasm [ 7 ]. novritsch ssg96 academyWebWe have demonstrated that cisplatin down-regulates the expression of the taurine transporter gene (TauT) in renal cells and that forced overexpression of TauT protects against... nickname associated with albertWebApr 25, 2024 · Taurine transport is mainly achieved by taurine transporters (TauT). In normal tissues, the intracellular concentration of taurine is much higher than the … novritsch shop wienWebJan 4, 2002 · Gene expression of TauT and taurine biosynthetic enzymes was estimated by measuring TauT, CDO, and CSD mRNA levels in cell RNA extracts through RT-PCR assays that we have developed according to published cDNA sequences of TauT ( 27 ), CDO ( 12 ), and CSD ( 29 ). MATERIALS AND METHODS Astrocyte primary cultures nickname checoWebAug 30, 2024 · Taurine transporter (TauT) has been identified as a target gene of p53 tumor suppressor and Wilms’ tumor suppressor gene, as well as c-Jun and c-Myc oncogenes (Han et al. 2006), respectively. TauT is also found to be overexpressed in variety type of human cancers, such as leukemia (Learn et al. 1990 ). novritsch ssg-10 a1WebJan 28, 2015 · Our results demonstrated that both homozygous and heterozygous TauT gene deletion predispose C57BL/6 mice to develop end-stage diabetic kidney disease, which closely replicates the pathological ... novritsch softairWebAug 15, 2004 · TauT promoter activity is regulated through a TonE/TonEBP pathway ( A) Cells were transfected with p2xTonE-Luc. Cells were cultured 24 h after transfection in isotonic (iso) or hypertonic media (NaCl+50 or Suc 100) for 24 h. Results were obtained from three experiments. nickname allison